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Antioxidant and Pro‐Oxidant Evaluation of a Potentilla alba L. Rhizome Extract
Author(s) -
Damien Dorman H. J.,
Shikov Alexander N.,
Pozharitskaya Olga N.,
Hiltunen Raimo
Publication year - 2011
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201100043
Subject(s) - potentilla , chemistry , dpph , rhizome , antioxidant , hydroxyl radical , flavonoid , flavonols , chelation , flavanone , biochemistry , botany , traditional medicine , organic chemistry , biology , medicine
Using spectrophotometric methods, a H 2 O‐soluble Potentilla alba L. rhizome extract was evaluated phytochemically, i.e. , the total phenol, flavonoid, flavonol, flavanone, and proanthocyanidin contents were determined, and its antioxidant and pro‐oxidant properties, i.e. , the Fe III reductive and the Fe II chelating properties, the 1,1‐diphenyl‐2‐picrylhydrazyl radical (DPPH . ), N , N ‐dimethyl‐ p ‐phenylenediamine (DMPD .+ ), and superoxide anion radical (O $\rm{{_{2}^{{^\cdot} -}}}$ )‐scavenging activities, the capacity to inhibit hydroxyl radical (HO . )‐mediated deoxy‐ D ‐ribose and phospholipid degradation, and the interaction with the Cu‐catalyzed HO . ‐mediated DNA degradation, were determined. The extract was found to contain a range of phenolic compounds recognized to possess strong antioxidant‐like properties. Moreover, the extract demonstrated dose‐dependent activities in all the antioxidant assays with the exception of the DNA‐degradation assay, where the components within the extract interfered with the assay components at concentrations ≥1.00 mg/ml. Potentilla species are known for their curative properties, with aerial/subterranean parts being prescribed for numerous indications. The data presented here suggests, though does not conclude, that the rhizomes contain compounds possessing a range of antioxidant‐related properties, which may underpin the therapeutic, viz. , anti‐inflammatory and adaptogenic effects, ascribed to species of this genus.