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Biologically Active Bergenin Derivatives from Bergenia stracheyi
Author(s) -
Siddiq Farah,
Fatima Itrat,
Malik Abdul,
Afza Nighat,
Iqbal Lubna,
Lateef Mehreen,
Hameed Saira,
Khan Sher Wali
Publication year - 2012
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201100003
Subject(s) - bergenin , chemistry , dpph , antioxidant , stereochemistry , biological activity , organic chemistry , biochemistry , in vitro
Abstract New bergenin derivatives, bergecins A and B ( 1 and 2 , resp.), have been isolated from the AcOEt‐soluble fraction of Bergenia stracheyi , along with bergenin ( 3 ), and their structures were elucidated on the basis of 1 H‐ and 13 C‐NMR spectra, and by COSY, HMQC, and HMBC experiments. Compound 2 showed potent inhibitory potential against the enzyme lipoxygenase, while 1 was moderately active. On the other hand, both compounds exhibited significant antioxidant activities in 1,1‐diphenyl‐2‐picrylhydrazyl (DPPH) scavenging assay.