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Conidiogenones H and I, Two New Diterpenes of Cyclopiane Class from a Marine‐Derived Endophytic Fungus Penicillium chrysogenum QEN‐24S
Author(s) -
Gao ShuShan,
Li XiaoMing,
Zhang Yi,
Li ChunShun,
Wang BinGui
Publication year - 2011
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201000378
Subject(s) - penicillium chrysogenum , fungus , staphylococcus epidermidis , antimicrobial , pseudomonas fluorescens , penicillium , chemistry , microbiology and biotechnology , staphylococcus aureus , stereochemistry , botany , biology , bacteria , genetics
Two new tetracyclic diterpenes of the rarely reported cyclopiane class, conidiogenones H and I ( 1 and 2 , resp.), along with five related congeners, conidiogenones B – D and F ( 3 – 5 and 6 , resp.) and conidiogenol ( 7 ), were characterized from the culture extracts of Penicillium chrysogenum QEN‐24S, an endophytic fungus derived from an unidentified marine red algal species of the genus Laurencia. The structures of these compounds were established on the basis of extensive spectroscopic analysis. The inhibitory activity of theses diterpenes against four bacteria and one pathogen fungus was evaluated. Conidiogenone B ( 3 ) showed potent activity against Methicillin resistant Staphylococcus aureus (MRSA), Pseudomonas fluorescens, P. aeruginosa , and Staphylococcus epidermidis (each with a MIC value of 8 μg/ml), while conidiogenol ( 7 ) showed obvious activity against P. fluorescens and S. epidermidis (each with a MIC value of 16 μg/ml). This is the first report on antimicrobial activity of cyclopiane diterpenes.