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Phenolic Compounds of Abies nephrolepis and Their NO Production Inhibitory Activities
Author(s) -
Li YongLi,
Wu Liang,
Ouyang DanWei,
Yu Ping,
Xia JiaHan,
Pan YueXing,
Yang XianWen,
Zeng HuaWu,
Cheng XiangRong,
Jin HuiZi,
Zhang WeiDong
Publication year - 2011
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201000373
Subject(s) - chemistry , phenols , inhibitory postsynaptic potential , two dimensional nuclear magnetic resonance spectroscopy , stereochemistry , organic chemistry , biology , neuroscience
Abstract Two new, i.e. , 1 and 2 , and 69 known phenolics were isolated from the aerial parts of Abies nephrolepis. These chemical constituents included 22 lignans, 30 flavonoids, and 19 other phenols. Their structures were determined mainly by analysis of the 1D‐ and 2D‐NMR spectroscopic data. All the 71 isolates were evaluated for their inhibitory activities against lipopolysaccharide (LPS)‐induced NO production in RAW 264.7 macrophages. Compound 1 exhibited a potent effect with an IC 50 value of 13.7 μg/ml.