Two New Imidazolone‐Containing Alkaloids and Further Metabolites from the Ascomycete Fungus  Tricladium  sp. | Zendy

Zou Xianwei | Zendy; Liu Shuchun | Zendy; Zheng Zhihui | Zendy; Zhang Hua | Zendy; Chen Xulin | Zendy; Liu Xingzhong | Zendy; Li Erwei | Zendy

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Two New Imidazolone‐Containing Alkaloids and Further Metabolites from the Ascomycete Fungus Tricladium sp.

Author(s) -

Zou Xianwei,

Liu Shuchun,

Zheng Zhihui,

Zhang Hua,

Chen Xulin,

Liu Xingzhong,

Li Erwei

Publication year - 2011

Publication title -

chemistry and biodiversity

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.427

H-Index - 70

eISSN - 1612-1880

pISSN - 1612-1872

DOI - 10.1002/cbdv.201000372

Subject(s) - chemistry , fungus , metabolite , stereochemistry , cytotoxicity , acetamide , biochemistry , botany , organic chemistry , biology , in vitro

Tricladins A and B ( 1 and 2 , resp.), new imidazolone‐containing alkaloids, together with five known metabolites, bacillamides A, B ( 3 and 4 , resp.), 20‐hydroxyaflavinine ( 5 ), N ‐(2‐phenylethyl)acetamide ( 6 ), and N b ‐acetyltryptamine ( 7 ), have been isolated from the crude extract of the ascomycete fungus Tricladium sp. The structures of 1 and 2 were elucidated primarily by NMR and MS methods. Compound 2 showed marginal cytotoxicity against MDA‐MB‐231 human breast cancer cells, whereas the known metabolite 4 displayed an inhibitory effect on HIV‐1 replication in C8166 cells.

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