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Two New Imidazolone‐Containing Alkaloids and Further Metabolites from the Ascomycete Fungus Tricladium sp.
Author(s) -
Zou Xianwei,
Liu Shuchun,
Zheng Zhihui,
Zhang Hua,
Chen Xulin,
Liu Xingzhong,
Li Erwei
Publication year - 2011
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201000372
Subject(s) - chemistry , fungus , metabolite , stereochemistry , cytotoxicity , acetamide , biochemistry , botany , organic chemistry , biology , in vitro
Tricladins A and B ( 1 and 2 , resp.), new imidazolone‐containing alkaloids, together with five known metabolites, bacillamides A, B ( 3 and 4 , resp.), 20‐hydroxyaflavinine ( 5 ), N ‐(2‐phenylethyl)acetamide ( 6 ), and N b ‐acetyltryptamine ( 7 ), have been isolated from the crude extract of the ascomycete fungus Tricladium sp. The structures of 1 and 2 were elucidated primarily by NMR and MS methods. Compound 2 showed marginal cytotoxicity against MDA‐MB‐231 human breast cancer cells, whereas the known metabolite 4 displayed an inhibitory effect on HIV‐1 replication in C8166 cells.