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Phenolic Derivatives from Ruprechtia polystachya and Their Inhibitory Activities on the Glucose‐6‐phosphatase System
Author(s) -
Bruzual De Abreu Maryan,
Temraz Abeer,
Malafronte Nicola,
GonzalezMujica Freddy,
Duque Sandra,
Braca Alessandra
Publication year - 2011
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201000334
Subject(s) - chemistry , inhibitory postsynaptic potential , biochemistry , phosphatase , enzyme , endocrinology , biology
Two new compounds, 5‐methyl‐2‐(2‐methylbutanoyl)phloroglucinol 1‐ O ‐(6‐ O ‐ β ‐ D ‐apiofuranosyl)‐ β ‐ D ‐glucopyranoside ( 1 ) and trans ‐2,3‐dihydrokaempferol 3‐ O ‐(4‐ O ‐sulfo)‐ α ‐ L ‐arabinopyranoside ( 2 ), together with 14 known flavonoids, trans ‐dihydrokaempferol 3‐ O ‐ α ‐ L ‐arabinopyranoside ( 3 ), trans ‐taxifolin 3‐ O ‐ α ‐ L ‐arabinofuranoside ( 4 ), quercetin 3‐ O ‐ α ‐ L ‐rhamnopyranoside ( 5 ), quercetin 3′‐ O ‐ α ‐ L ‐arabinofuranoside ( 6 ), catechin 3‐ O ‐ α ‐ L ‐rhamnopyranoside ( 7 ), trans ‐taxifolin 3‐ O ‐ α ‐ L ‐arabinopyranoside ( 8 ), cis ‐dihydrokaempferol 3‐ O ‐ α ‐ L ‐arabinopyranoside ( 9 ), catechin ( 10 ), myricetin 3‐ O ‐ α ‐ L ‐rhamnopyranoside ( 11 ), quercetin 3‐ O ‐ α ‐ L ‐arabinopyranoside ( 12 ), quercetin 3‐ O ‐ α ‐ L ‐arabinofuranoside ( 13 ), quercetin 3‐ O ‐(3″‐galloyl)‐ α ‐ L ‐rhamnopyranoside ( 14 ), quercetin 3‐ O‐ (2″‐galloyl)‐ α ‐ L ‐rhamnopyranoside ( 15 ), and epicatechin 3‐ O ‐gallate ( 16 ), were isolated from the leaves of Ruprechtia polystachya Griseb. (Polygonaceae). Their structures were established on the basis of extensive 1D‐ and 2D‐NMR experiments as well as MS analyses. All compounds, except 1 , showed inhibition of the enzyme glucose‐6‐phosphatase in intact microsomes.