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Sesquiterpenoids and Lignans from the Roots of Valeriana officinalis L.
Author(s) -
Wang PengCheng,
Ran XinHui,
Chen Rui,
Luo HuaiRong,
Ma QingYun,
Liu YuQing,
Hu JiangMiao,
Huang ShengZhuo,
Jiang HeZhong,
Chen ZhongQuan,
Zhou Jun,
Zhao YouXing
Publication year - 2011
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201000247
Subject(s) - chemistry , stereochemistry , acetylcholinesterase , aché , two dimensional nuclear magnetic resonance spectroscopy , officinalis , pinoresinol , lignan , biochemistry , enzyme , botany , biology
Two new guaiane‐type sesquiterpenoids, valerol A ( 1 ) and kessyl 3‐acetate ( 2 ), together with nine known compounds, valeracetate ( 3 ), anismol A ( 4 ), orientalol C ( 5 ), spatulenol ( 6 ), 4 α ,10 α ‐epoxyaromadendrane ( 7 ), (+)‐8‐hydroxypinoresinol ( 8 ), pinorespiol ( 9 ), pinoresinol 4‐ O ‐ β ‐ D ‐glucopyranoside ( 10 ), and 8‐hydroxypinoresinol 4′‐ O ‐ β ‐ D ‐glucopyranoside ( 11 ) were isolated from the roots of Valeriana officinalis. The structures and relative configurations of 1 and 2 were elucidated on the basis of spectroscopic methods (1D‐ and 2D‐NMR, MS, UV, and IR). These compounds were evaluated for inhibitory activity on acetylcholinesterase (AChE) and enhancing activity on nerve growth factor (NGF)‐mediated neurite outgrowth in PC12 cells.