Novel Terpenoids from  Calocedrus macrolepis  var.  formosana | Zendy

Hsieh ChinLin | Zendy; Tseng MeiHwei | Zendy; Pan RyhNan | Zendy; Chang JangYang | Zendy; Kuo ChingChuan | Zendy; Lee TzongHuei | Zendy; Kuo YuehHsiung | Zendy

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Novel Terpenoids from Calocedrus macrolepis var. formosana

Author(s) -

Hsieh ChinLin,

Tseng MeiHwei,

Pan RyhNan,

Chang JangYang,

Kuo ChingChuan,

Lee TzongHuei,

Kuo YuehHsiung

Publication year - 2011

Publication title -

chemistry and biodiversity

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.427

H-Index - 70

eISSN - 1612-1880

pISSN - 1612-1872

DOI - 10.1002/cbdv.201000237

Subject(s) - terpenoid , chemistry , terpene , bark (sound) , traditional medicine , stereochemistry , biology , medicine , ecology

Calocetriol ( 1 ), diacetylcalocediol ( 2 ), and ferrugimenthenol ( 3 ) were isolated from the bark of Calocedrus macrolepis var. formosana. Among them, 1 and 2 are secoabietane‐type diterpenoids, and 3 , with a novel C 20 C 10 skeleton, is classified as a meroterpenoid. The structures of 1 – 3 were elucidated by spectroscopic analyses, and their biological activities were also evaluated. Compound 3 exhibited significant cytotoxic activity against human oral epidermoid carcinoma KB cells with an IC 50 value of 9.0±0.1 μ M .

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