Premium
Novel Terpenoids from Calocedrus macrolepis var. formosana
Author(s) -
Hsieh ChinLin,
Tseng MeiHwei,
Pan RyhNan,
Chang JangYang,
Kuo ChingChuan,
Lee TzongHuei,
Kuo YuehHsiung
Publication year - 2011
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201000237
Subject(s) - terpenoid , chemistry , terpene , bark (sound) , traditional medicine , stereochemistry , biology , medicine , ecology
Calocetriol ( 1 ), diacetylcalocediol ( 2 ), and ferrugimenthenol ( 3 ) were isolated from the bark of Calocedrus macrolepis var. formosana. Among them, 1 and 2 are secoabietane‐type diterpenoids, and 3 , with a novel C 20 C 10 skeleton, is classified as a meroterpenoid. The structures of 1 – 3 were elucidated by spectroscopic analyses, and their biological activities were also evaluated. Compound 3 exhibited significant cytotoxic activity against human oral epidermoid carcinoma KB cells with an IC 50 value of 9.0±0.1 μ M .