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Synthesis, Characterization, Thermal Behavior, and DNA‐Cleaving Studies of Cyano‐Bridged Nickel(II)Copper(II) Complexes of 4‐(Pyridin‐2‐ylazenyl)resorcinol
Author(s) -
Karipcin Fatma,
Özmen İsmail,
Cülü Burcin,
Çelikoğlu Umut
Publication year - 2011
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201000209
Subject(s) - chemistry , ligand (biochemistry) , nickel , resorcinol , copper , perchlorate , agarose gel electrophoresis , metal , chelation , stoichiometry , inorganic chemistry , stereochemistry , crystallography , medicinal chemistry , dna , organic chemistry , ion , biochemistry , receptor
We present here the syntheses of a mononuclear Cu II complex and two polynuclear Cu II Ni II complexes of the azenyl ligand, 4‐(pyridin‐2‐ylazenyl)resorcinol (HL; 1). The reaction of HL ( 1 ) and copper(II) perchlorate with KCN gave a mononuclear complex [CuL(CN)] ( 4 ). Using 4 , one pentanuclear complex, [{CuL(NC)} 4 Ni](ClO 4 ) 2 ( 5 ) and one trinuclear complex, [{CuL(CN)} 2 NiL]ClO 4 ( 6 ), were prepared and characterized by elemental analyses, magnetic susceptibility, molar conductance, IR, and thermal analysis. Stoichiometric and spectral results of the mononuclear Cu II complex indicated that the metal/ligand/CN ratio was 1 : 1 : 1, and the ligand behaved as a tridentate ligand forming neutral metal chelates through the pyridinyl and azenyl N‐, and resorcinol O‐atom. The interaction between the compounds (the ligand 1 , its Ni II and Cu II complexes without CN, i.e. , 2 and 3 , and its complexes with CN, 4 – 6 ) and DNA has also been investigated by agarose gel electrophoresis. The pentanuclear Cu 4 Ni complex ( 5 ) with H 2 O 2 as a co‐oxidant exhibited the strongest DNA‐cleaving activity.