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Fasciculols H and I, Two Lanostane Derivatives from Chinese Mushroom Naematoloma fasciculare
Author(s) -
Shi XinWei,
Li XiaoJun,
Gao JinMing,
Zhang XingChang
Publication year - 2011
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201000203
Subject(s) - lanostane , chemistry , mushroom , agaricales , two dimensional nuclear magnetic resonance spectroscopy , terpene , stereochemistry , medicinal fungi , heteronuclear single quantum coherence spectroscopy , organic chemistry , botany , food science , triterpene , polysaccharide , medicine , taxonomy (biology) , alternative medicine , pathology , biology
Two new highly oxygenated fasciculol‐type lanostane derivatives, fasciculols H and I ( 1 and 2 , resp.), together with five known compounds, 3 – 7 , were isolated from the fruiting bodies of the Chinese toxic mushroom Naematoloma fasciculare. Their structures were elucidated on the basis of spectroscopic analyses including 2D‐NMR (HMBC, HSQC, NOESY, 1 H, 1 H‐COSY). Compounds 5 – 7 were identified for the first time in this mushroom. Compounds 1, 3, 4 , and 5 were evaluated for inhibitory activity against human glioma cell line U87 and nuclear factor‐ κ B.
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