Four New Cryptoporic Acid Derivatives from the Fruiting Bodies of  Cryptoporus sinensis , and Their Inhibitory Effects on Nitric Oxide Production | Zendy

Wu Wen | Zendy; Zhao Feng | Zendy; Ding Rong | Zendy; Bao Li | Zendy; Gao Hao | Zendy; Lu JinCai | Zendy; Yao XinSheng | Zendy; Zhang XiaoQing | Zendy; Liu HongWei | Zendy

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Four New Cryptoporic Acid Derivatives from the Fruiting Bodies of Cryptoporus sinensis , and Their Inhibitory Effects on Nitric Oxide Production

Author(s) -

Wu Wen,

Zhao Feng,

Ding Rong,

Bao Li,

Gao Hao,

Lu JinCai,

Yao XinSheng,

Zhang XiaoQing,

Liu HongWei

Publication year - 2011

Publication title -

chemistry and biodiversity

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.427

H-Index - 70

eISSN - 1612-1880

pISSN - 1612-1872

DOI - 10.1002/cbdv.201000184

Subject(s) - nitric oxide , chemistry , nitric acid , inhibitory postsynaptic potential , stereochemistry , biochemistry , organic chemistry , biology , neuroscience

Four new drimane‐type sesquiterpenoid ethers of isocitric acid, named cryptoporic acids J–M, were isolated from the fruiting bodies of Cryptoporus sinensis , together with six known cryptoporic acids. Their structures were elucidated on the basis of extensive spectroscopic analyses. Among them, cryptoporic acid D showed strong inhibition against nitric oxide (NO) production in macrophages with an IC 50 of 45.8±3.6 μ M , comparable to the positive control of hydrocortisone ( IC 50 of 40.6±2.5 μ M ).

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