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Four New Cryptoporic Acid Derivatives from the Fruiting Bodies of Cryptoporus sinensis , and Their Inhibitory Effects on Nitric Oxide Production
Author(s) -
Wu Wen,
Zhao Feng,
Ding Rong,
Bao Li,
Gao Hao,
Lu JinCai,
Yao XinSheng,
Zhang XiaoQing,
Liu HongWei
Publication year - 2011
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201000184
Subject(s) - nitric oxide , chemistry , nitric acid , inhibitory postsynaptic potential , stereochemistry , biochemistry , organic chemistry , biology , neuroscience
Four new drimane‐type sesquiterpenoid ethers of isocitric acid, named cryptoporic acids J–M, were isolated from the fruiting bodies of Cryptoporus sinensis , together with six known cryptoporic acids. Their structures were elucidated on the basis of extensive spectroscopic analyses. Among them, cryptoporic acid D showed strong inhibition against nitric oxide (NO) production in macrophages with an IC 50 of 45.8±3.6 μ M , comparable to the positive control of hydrocortisone ( IC 50 of 40.6±2.5 μ M ).