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A Highly Enantioselective Access to Chiral 1‐( β ‐Arylalkyl)‐1 H ‐1,2,4‐triazole Derivatives as Potential Agricultural Bactericides
Author(s) -
Lu WenChang,
Cao XiuFang,
Hu Ming,
Li Fei,
Yu GuangAo,
Liu ShengHua
Publication year - 2011
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201000180
Subject(s) - rhizoctonia solani , chemistry , botrytis cinerea , enantiomer , gibberella zeae , triadimefon , enantioselective synthesis , bioassay , fusarium , triazole , reagent , fungicide , antifungal , stereochemistry , organic chemistry , botany , biology , microbiology and biotechnology , genetics , catalysis
A series of chiral 1‐( β ‐arylalkyl)‐1 H ‐1,2,4‐triazole derivatives has been designed as potential antifungal agents. The target triazoles have been synthesized by using a chiral auxiliary as a controlling reagent. All of the compounds were obtained with high ee values, reaching up to 99%. Preliminary bioassay results have revealed that most of the synthesized compounds display significantly higher fungicidal activities against the species Fusarium oxysporium, Rhizoctonia solani, Botrytis cinereapers, Gibberella zeae, Dothiorella gregaria , and Colletotrichum gossypii than the commercial agent triadimefon. Moreover, some of the enantiomers have been found to display significant differences in activity.