Secondary Metabolites from  Saussurea deltoidea  and Their Inhibitory Activity on Lipopolysaccharide‐Induced Tumor Necrosis Factor Production | Zendy

Tung YuLin | Zendy; Cheng MingJen | Zendy; Hu NaiYun | Zendy; Shih YingChu | Zendy; Chiou ShuJiau | Zendy; Chen IhSheng | Zendy

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Secondary Metabolites from Saussurea deltoidea and Their Inhibitory Activity on Lipopolysaccharide‐Induced Tumor Necrosis Factor Production

Author(s) -

Tung YuLin,

Cheng MingJen,

Hu NaiYun,

Shih YingChu,

Chiou ShuJiau,

Chen IhSheng

Publication year - 2011

Publication title -

chemistry and biodiversity

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.427

H-Index - 70

eISSN - 1612-1880

pISSN - 1612-1872

DOI - 10.1002/cbdv.201000166

Subject(s) - chemistry , sesquiterpene , tumor necrosis factor alpha , fractionation , in vitro , lipopolysaccharide , bioassay , u937 cell , stereochemistry , biochemistry , chromatography , biology , immunology , genetics

Bioassay‐guided fractionation of the whole plants of Saussurea deltoidea led to the isolation and structure elucidation of one new sesquiterpene, deltoidealactone ( 1 ), together with 23 known compounds 2 – 24 . Their structures were established on the basis of extensive 1D‐ and 2D‐NMR analyses in combination with HR‐MS experiments. Deltoidealactone ( 1 ) inhibits tumor necrosis factor (TNF‐ α ) production in U937 cells in vitro with an IC 50 value of 1.47 μg/ml.

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