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Secondary Metabolites from Saussurea deltoidea and Their Inhibitory Activity on Lipopolysaccharide‐Induced Tumor Necrosis Factor Production
Author(s) -
Tung YuLin,
Cheng MingJen,
Hu NaiYun,
Shih YingChu,
Chiou ShuJiau,
Chen IhSheng
Publication year - 2011
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201000166
Subject(s) - chemistry , sesquiterpene , tumor necrosis factor alpha , fractionation , in vitro , lipopolysaccharide , bioassay , u937 cell , stereochemistry , biochemistry , chromatography , biology , immunology , genetics
Bioassay‐guided fractionation of the whole plants of Saussurea deltoidea led to the isolation and structure elucidation of one new sesquiterpene, deltoidealactone ( 1 ), together with 23 known compounds 2 – 24 . Their structures were established on the basis of extensive 1D‐ and 2D‐NMR analyses in combination with HR‐MS experiments. Deltoidealactone ( 1 ) inhibits tumor necrosis factor (TNF‐ α ) production in U937 cells in vitro with an IC 50 value of 1.47 μg/ml.