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New Cytotoxic Metabolites from a Deep‐Sea‐Derived Fungus, Phialocephala sp., Strain FL30r
Author(s) -
Li DeHai,
Cai ShengXin,
Zhu TianJiao,
Wang FengPing,
Xiao Xiang,
Gu QianQun
Publication year - 2011
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201000134
Subject(s) - fungus , cytotoxic t cell , chemistry , stereochemistry , strain (injury) , derivative (finance) , botany , biology , biochemistry , in vitro , anatomy , economics , financial economics
Two new sorbicillinoids, 1 and 2 , together with a novel benzofuranone derivative named phialofurone ( 3 ), were isolated from a deep‐sea sediment‐derived fungus, Phialocephala sp . Their structures were established on the basis of spectroscopic data. All compounds displayed cytotoxic effects against P388 ( IC 50 values of 11.5±1.4, 0.1±0.1, and 0.2±0.01 μ M , resp.) and K562 ( IC 50 values of 22.9±0.8, 4.8±0.3 and 22.4±0.9 μ M , resp.) cell lines.
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