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Patagonicosides B and C, Two Antifungal Sulfated Triterpene Glycosides from the Sea Cucumber Psolus patagonicus
Author(s) -
Careaga Valeria P.,
Muniain Claudia,
Maier Marta S.
Publication year - 2011
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201000044
Subject(s) - sea cucumber , triterpene , glycoside , chemistry , stereochemistry , antifungal , two dimensional nuclear magnetic resonance spectroscopy , terpene , fungus , heteronuclear single quantum coherence spectroscopy , traditional medicine , botany , microbiology and biotechnology , biology , ecology , medicine , alternative medicine , pathology
Two new triterpene glycosides, patagonicosides B and C ( 2 and 3 , resp.), together with the known patagonicoside A ( 1 ), have been isolated from the EtOH extract of the sea cucumber Psolus patagonicus. The structures of the new compounds were established on the basis of extensive NMR spectroscopic analysis ( 1 H‐ and 13 C‐NMR, 1 H, 1 H‐COSY, HMBC, HSQC, TOCSY, and NOESY), HR‐ESI‐MS data, and chemical transformations. Compounds 1 – 3 and their desulfated analogs showed antifungal activities against the phytopathogenic fungus Cladosporium cladosporoides in a dose‐dependent fashion.
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