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A New Taxane with an Opened Oxetane Ring from the Needles of Taxus cuspidata
Author(s) -
Cheng Ming,
Dong Mei,
Li Yong,
Sauriol Francoise,
Shi QingWen
Publication year - 2010
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201000017
Subject(s) - chemistry , oxetane , taxane , taxoid , stereochemistry , two dimensional nuclear magnetic resonance spectroscopy , organic chemistry , paclitaxel , medicine , surgery , chemotherapy , cancer , breast cancer
A new taxoid metabolite was isolated from the MeOH extract of Taxus cuspidata needles. The structure was established as (2 α ,5 α ,7 β ,9 α ,10 β ,13 α )‐10,13,20‐tris(acetyloxy)‐1,4,5,7,9‐pentahydroxytax‐11‐en‐2‐yl benzoate ( 1 ) on the basis of spectral analyses including 1 H‐ and 13 C‐NMR, HMQC, HMBC, and NOESY, and confirmed by HR‐FAB‐MS.