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Two New Resveratrol Tetramers Isolated from Cayratia japonica ( Thunb. ) Gagn. with Strong Inhibitory Activity on Fatty Acid Synthase and Antioxidant Activity
Author(s) -
Bao Li,
Ma Xiaofeng,
Song Xiaohong,
Wang Manyuan,
Liu Hongwei
Publication year - 2010
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.200900394
Subject(s) - chemistry , antioxidant , inhibitory postsynaptic potential , resveratrol , fatty acid synthase , biochemistry , fatty acid , neuroscience , biology
Two new resveratrol tetramers, cajyphenol A ( 1 ) and cajyphenol B ( 2 ), together with two known resveratrol dimers, quadrangularin A ( 3 ) and pallidol ( 4 ), and resveratrol ( 5 ) were isolated from the stems of Cayratia japonica ( Thunb. ) Gagn. Their structures were established by means of NMR ( 1 H, 1 H‐COSY, 1 H, 13 C‐HSQC, HMBC, and NOESY) and ESI‐MS analyses. Compounds 1 – 5 showed fast‐binding inhibitory activities on fatty acid synthase with the IC 50 values of 1.63±0.02, 1.49±0.03, 7.50±0.01, 11.1±0.01, and 10.2±0.01 μ M , respectively. Compounds 1 – 5 also exhibited antioxidant activities in the ORAC assay.