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Regulation of the 5‐HT 3 A Receptor‐Mediated Current by Alkyl 4‐Hydroxybenzoates Isolated from the Seeds of Nelumbo nucifera
Author(s) -
Joung Youn Ui,
Lee JunHo,
Lee Yoo Jin,
Nam Joo Won,
Bae Hyunsu,
Seo EunKyoung
Publication year - 2010
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.200900393
Subject(s) - chemistry , nelumbo nucifera , alkyl , receptor , current (fluid) , stereochemistry , botany , biochemistry , organic chemistry , biology , lotus , oceanography , geology
Four known alkyl 4‐hydroxybenzoates, i.e. , methyl 4‐hydroxybenzoate ( 1 ), ethyl 4‐hydroxybenzoate ( 2 ), propyl 4‐hydroxybenzoate ( 3 ), and butyl 4‐hydroxybenzoate ( 4 ), were isolated from the seeds of Nelumbo nucifera Gaertner (Nymphaeaceae) for the first time. The structures of the isolates were identified by 1D‐ and 2D‐NMR spectroscopy and comparison with published values. The compounds were evaluated for their effects on the 5‐HT‐stimulated inward current ( I 5‐HT ) mediated by the human 5‐HT 3 A receptors expressed in Xenopus oocytes. Compounds 1 and 2 enhanced the I 5‐HT , but 4 reduced it. These results indicate that 4 is an inhibitor of the 5‐HT 3 A receptors expressed in Xenopus oocytes.