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6,7 ‐seco‐ent‐ Kaurane Diterpenoids from Isodon sculponeatus with Cytotoxic Activity
Author(s) -
Li Xian,
Pu JianXin,
Weng ZhiYing,
Zhao Yu,
Zhao Yong,
Xiao WeiLie,
Sun HanDong
Publication year - 2010
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.200900302
Subject(s) - chemistry , stereochemistry , cytotoxicity , diterpene , two dimensional nuclear magnetic resonance spectroscopy , cytotoxic t cell , biochemistry , in vitro
Six new 6,7‐ seco ‐ ent ‐kaurane diterpenoids, sculponeatins N–S ( 1 – 6 , resp.), together with eleven known analogues, 7 – 17 , were isolated from the aerial parts of Isodon sculponeatus. The structures of compounds 1 – 6 were elucidated by spectroscopic methods including extensive 1D‐ and 2D‐NMR experiments, as well as HR‐ESI‐MS analysis. All diterpenoids obtained were assayed for their cytotoxic activity against K562 and HepG2 human tumor cell lines. Among them, compound 1 showed the most significant cytotoxicity with the IC 50 values of 0.21 and 0.29 μ M , respectively. The structure–activity relationships are discussed.