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A New Quinolone and Other Constituents from the Fruits of Tetradium ruticarpum : Effects on Neutrophil Pro‐Inflammatory Responses
Author(s) -
Wang TzuYing,
Wu JinBin,
Hwang TsongLong,
Kuo YuehHsiung,
Chen JihJung
Publication year - 2010
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.200900289
Subject(s) - chemistry , evodiamine , rutaecarpine , pharmacology , stereochemistry , medicine , chromatography
The fruit of Tetradium ruticarpum is widely used in healthcare products for the improvement of blood circulation, headache, abdominal pain, amenorrhea, chill limbs, migraine, and nausea. A new quinolone, 2‐[(6 Z ,9 Z )‐pentadeca‐6,9‐dienyl]quinolin‐4(1 H )‐one ( 1 ), has been isolated from the fruits of T. ruticarpum , together with eleven known compounds. The structure of the new compound was determined by NMR and MS analyses. Rutaecarpine ( 4 ), evodiamine ( 5 ), and skimmianine ( 7 ) exhibited inhibition ( IC 50 ≤20.9 μ M ) of O $\rm{{_{2}^{{^\cdot} -}}}$ generation by human neutrophils in response to N ‐formyl‐ L ‐methionyl‐ L ‐leucyl‐ L ‐phenylalanine/cytochalasin B (fMLP/CB). In addition, 1 , evocarpine ( 2 ), 4, 7 , and evodol ( 8 ) inhibited fMLP/CB‐induced elastase release with IC 50 values ≤14.4 μ M .