A New Quinolone and Other Constituents from the Fruits of  Tetradium ruticarpum : Effects on Neutrophil Pro‐Inflammatory Responses | Zendy

Wang TzuYing | Zendy; Wu JinBin | Zendy; Hwang TsongLong | Zendy; Kuo YuehHsiung | Zendy; Chen JihJung | Zendy

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A New Quinolone and Other Constituents from the Fruits of Tetradium ruticarpum : Effects on Neutrophil Pro‐Inflammatory Responses

Author(s) -

Wang TzuYing,

Wu JinBin,

Hwang TsongLong,

Kuo YuehHsiung,

Chen JihJung

Publication year - 2010

Publication title -

chemistry and biodiversity

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.427

H-Index - 70

eISSN - 1612-1880

pISSN - 1612-1872

DOI - 10.1002/cbdv.200900289

Subject(s) - chemistry , evodiamine , rutaecarpine , pharmacology , stereochemistry , medicine , chromatography

The fruit of Tetradium ruticarpum is widely used in healthcare products for the improvement of blood circulation, headache, abdominal pain, amenorrhea, chill limbs, migraine, and nausea. A new quinolone, 2‐[(6 Z ,9 Z )‐pentadeca‐6,9‐dienyl]quinolin‐4(1 H )‐one ( 1 ), has been isolated from the fruits of T. ruticarpum , together with eleven known compounds. The structure of the new compound was determined by NMR and MS analyses. Rutaecarpine ( 4 ), evodiamine ( 5 ), and skimmianine ( 7 ) exhibited inhibition ( IC 50 ≤20.9 μ M ) of O $\rm{{_{2}^{{^\cdot} -}}}$ generation by human neutrophils in response to N ‐formyl‐ L ‐methionyl‐ L ‐leucyl‐ L ‐phenylalanine/cytochalasin B (fMLP/CB). In addition, 1 , evocarpine ( 2 ), 4, 7 , and evodol ( 8 ) inhibited fMLP/CB‐induced elastase release with IC 50 values ≤14.4 μ M .

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