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New Biological Functions and Applications of High‐Molecular‐Mass Poly‐ γ ‐glutamic Acid
Author(s) -
Poo Haryoung,
Park Chung,
Kwak MiSun,
Choi DooYeol,
Hong SeungPyo,
Lee IlHan,
Lim Yong Taik,
Choi Young Ki,
Bae SunRyang,
Uyama Hiroshi,
Kim ChulJoong,
Sung MoonHee
Publication year - 2010
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.200900283
Subject(s) - chemistry , glutamic acid , computational biology , biophysics , combinatorial chemistry , nanotechnology , biochemistry , amino acid , biology , materials science
Ultra‐high‐molecular‐weight poly‐ γ ‐glutamic acid ( γ ‐PGA) is a most promising biodegradable polymer that is produced by Bacillus subtilis (chungkookjang). Attractive properties of γ ‐PGA are that it is water soluble, anionic, biodegradable, and edible. Development of γ ‐PGA has pursued in terms of cosmetics/skin care, bone care, nanoparticle for drug delivery system, hydrogel, and so on. Very recently, our research has shown that γ ‐PGA can be used as an immune‐stimulating agent, especially at high molecular weight. This review presents the synthesis and production of high‐molecular‐weight γ ‐PGA and its various applications in industrial fields.