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The Resurgence of Acyclic Nucleic Acids
Author(s) -
Zhang Su,
Switzer Christopher,
Chaput John C.
Publication year - 2010
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.200900281
Subject(s) - nucleic acid , chemistry , rna , nucleoside , nucleic acid structure , dna , computational biology , nucleic acid methods , biochemistry , combinatorial chemistry , biology , gene
This review examines acyclic nucleoside analogs as therapeutic agents, potential progenitor candidates to RNA, and novel building blocks for nucleic‐acid nanotechnology. Together, these areas of research provide new insights into the structural and functional properties of nucleic acids and suggest new paradigms for nucleic acid self‐assembly.