Premium
BACE1 (Beta‐Secretase) Inhibitory Phenolic Acids and a Novel Sesquiterpenoid from Homalomena occulta
Author(s) -
Tian XiaoYan,
Zhao Ying,
Yu ShiShan,
Fang WeiShuo
Publication year - 2010
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.200900280
Subject(s) - chemistry , benzoic acid , stereochemistry , inhibitory postsynaptic potential , sesquiterpene , chloroform , biochemistry , organic chemistry , biology , neuroscience
Four phenolic acids, namely 2‐[( Z )‐heptadec‐11‐enyl]‐6‐hydroxybenzoic acid ( 1 ), 2‐[(6 Z ,9 Z ,12 Z )‐heptadeca‐6,9,12‐trienyl]‐6‐hydroxybenzoic acid ( 2 ), 2‐[(9 Z ,12 Z )‐heptadeca‐9,12‐dienyl] ‐ 6 ‐ hydroxybenzoic acid ( 3 ), and 2‐hydroxy‐6‐(12‐phenyldodecyl)benzoic acid ( 4 ), and one sesquiterpene, asperpenoid ( 5 ), were isolated from the 95% EtOH extract of the roots of Homalomena occulta , among which 1, 2 , and 5 represent new compounds. Further, the phenolic acids 1 – 4 exhibited BACE1 ( β ‐secretase) inhibitory activity with IC 50 values of 6.23±0.94, 6.28±0.63, 7.93±0.38, and 7.65±0.62 μ M , respectively.