Premium
Triterpenoid Alkaloids from Buxus microphylla
Author(s) -
Yan YuXin,
Chen JianChao,
Sun Yun,
Wang YuanYuan,
Su Jia,
Li Yan,
Qiu MingHua
Publication year - 2010
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.200900259
Subject(s) - chemistry , triterpenoid , stereochemistry , cytotoxicity , two dimensional nuclear magnetic resonance spectroscopy , botany , biochemistry , in vitro , biology
Two new triterpenoid alkaloids, buxmicrophyllines J and K ( 1 and 2 , resp.), together with four analogues, 3 – 6 , were isolated from the leaves and stems of Buxus microphylla. The structures of the new compounds were elucidated by NMR and MS spectroscopic analyses. The partial assignments of the NMR spectra of 3 were also revised. Compounds 1 and 3 – 6 were evaluated for their growth inhibitory activity against human cell lines HL‐60, SMMC‐7721, A‐549, SK‐BR‐3, and PANC‐1. Compound 6 showed significant cytotoxicity against HL‐60, SK‐BR‐3, and PANC‐1 cell lines, with IC 50 values of 6.46, 19.61, and 28.57 μ M , respectively.