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Prenylated Benzophenone Peroxide Derivatives from Hypericum sampsonii
Author(s) -
Xiao Zhi Yong,
Zeng Yi Han,
Mu Qing,
Shiu Winnie Ka Po,
Gibbons Simon
Publication year - 2010
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.200900247
Subject(s) - benzophenone , chemistry , peroxide , moiety , staphylococcus aureus , prenylation , stereochemistry , organic chemistry , bacteria , biology , genetics , enzyme
Two new prenylated benzophenone peroxide derivatives, peroxysampsones A and B ( 1 and 2 , resp.), together with a known compound, plukenetione C ( 3 ), were isolated from the roots of the Chinese medicinal plant Hypericum sampsonii , and their structures were elucidated by detailed spectral analysis. These compounds are the unusual peroxides of polyprenylated benzophenone derivatives, containing the unique caged moiety of 4,5‐dioxatetracyclo[9.3.1.1 9,13 .0 1,7 ]hexadecane‐12,14,15‐trione. In the biological test, peroxysampsone A ( 1 ) showed comparable activity with norfloxacin against a NorA over‐expressing multidrug‐resistant (MDR) strain of Staphylococcus aureus SA‐1199B.