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A New Long‐Chain Alkene and Antituberculosis Constituents from the Leaves of Pourthiaea lucida
Author(s) -
Chen JihJung,
Lin WenJiou,
Shieh PoChuen,
Chen IhSheng,
Peng ChienFang,
Sung PingJyun
Publication year - 2010
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.200900198
Subject(s) - chemistry , alkene , stereochemistry , phytol , mycobacterium tuberculosis , organic chemistry , tuberculosis , biochemistry , medicine , pathology , catalysis
A new long‐chain alkene, dotriacont‐1‐ene ( 1 ), was isolated from the leaves of Pourthiaea lucida , together with twelve known compounds. The structure of this new compound was determined by NMR and mass‐spectrometric analyses. Among the isolated compounds, α ‐tocospiro A ( 2 ), α ‐tocopheryl quinone ( 4 ), and ( E )‐phytol ( 5 ) exhibited antituberculosis activities ( MIC s ≤30 μg/ml) against Mycobacterium tuberculosis H 37 Rv in vitro.