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Nucleic Acids with a Six‐Membered ‘Carbohydrate’ Mimic in the Backbone
Author(s) -
Herdewijn Piet
Publication year - 2010
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.200900185
Subject(s) - nucleic acid , chemistry , pyranose , nucleic acid structure , moiety , biochemistry , carbohydrate , stereochemistry , rna , gene
Starting from pyranose nucleic acids, several series of modified nucleic acids with a six‐membered carbohydrate moiety (mimic) have been synthesized and analyzed over a period of 20 years, and this work is summarized here. The process starts with structural and conformational considerations, followed by synthetic efforts and a structural analysis, and ends up with a biological confirmation of the concept, demonstrating that these modified nucleic acids represent very valuable tools in chemistry and biology.