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The Chemical Constituents of Endophytic Fungus Trichoderma sp. MFF‐1
Author(s) -
Li GuoHong,
Wang XingBiao,
Liu FangFang,
Dang LiZhi,
Li Lei,
Yang ZhongShan,
Xin Xiong,
Zhang KeQin
Publication year - 2010
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.200900175
Subject(s) - chemistry , antimicrobial , stereochemistry , strain (injury) , bacillus cereus , trichoderma , fungus , candida albicans , microbiology and biotechnology , organic chemistry , botany , bacteria , biology , genetics , anatomy
Abstract A fungal strain named MFF‐1 was isolated from the flower of Pyrethrum cinerariifolium. Based on the sequence at the internal transcribed spacer (ITS) region, this strain was identified as a Trichoderma sp. Two new compounds, including a mitorubrin derivative and its potential biogenetic precursor, together with a known compound, were isolated from the cultures of the endophytic fungus. Their structures were established by spectroscopic methods and determined to be (3 S* ,6 R* ,7 R* )‐3,4,5,6,7,8‐hexahydro‐7‐hydroxy‐7‐methyl‐8‐oxo‐3‐[( E )‐prop‐1‐enyl]‐1 H ‐isochromen‐6‐yl 2,4‐dihydroxy‐6‐methylbenzoate ( 1 ), named deacetylisowortmin, ( E )‐2‐(hydroxymethyl)‐3‐(2‐hydroxypent‐3‐enyl)phenol ( 2 ), and wortmannin ( 3 ). All compounds were assayed for antimicrobial activity. Compound 3 showed activity against Candida albicans and Bacillus cereus.