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Four New Sesquiterpenes from Curcuma wenyujin and Their Inhibitory Effects on Nitric‐Oxide Production
Author(s) -
Lou Yan,
Zhao Feng,
He Hao,
Peng KaiFeng,
Chen LiXia,
Qiu Feng
Publication year - 2010
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.200900160
Subject(s) - sesquiterpene , nitric oxide , chemistry , sesquiterpene lactone , stereochemistry , terpene , traditional medicine , organic chemistry , medicine
Four new sesquiterpenes including the novel sesquiterpene lactone (6 R )‐dehydroxysipanolinolide ( 1 ), two new eudesmane‐type sesquiterpenes, curcolide ( 2 ) and curcodione ( 3 ), and a new xanthane‐type sesquiterpene, curcumadionol ( 4 ), were isolated from Curcuma wenyujin Y. H. Chen et C. Ling , together with five known ones, 5 – 9 . The structures of the new compounds were elucidated by spectroscopic methods. The inhibitory effects of compounds 1 – 9 on nitric‐oxide production in lipopolysaccaride‐activated macrophages were evaluated.