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A New Prenylated Flavanonol from Seseli annuum Roots Showing Protective Effect on Human Lymphocytes DNA
Author(s) -
Vučković Ivan,
Vajs Vlatka,
Stanković Miroslava,
Tešević Vele,
Milosavljević Slobodan
Publication year - 2010
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.200900067
Subject(s) - chemistry , furanocoumarin , prenylation , micronucleus , in vitro , dna , cytochalasin , micronucleus test , two dimensional nuclear magnetic resonance spectroscopy , cytochalasin b , stereochemistry , biochemistry , cell , cytoskeleton , toxicity , organic chemistry , enzyme
A new prenylated flavanonol named seselinonol ( 1 ) was isolated from the roots of Seseli annuum , together with the well‐known biologically active polyacetylenes falcarinol ( 2 ) and falcarindiol ( 3 ), and the prenylated furanocoumarin phellopterin ( 4 ). Its structure was elucidated by extensive spectroscopic analysis, including HR‐ESI‐MS, 1D‐ and 2D‐NMR. Seselinonol and phellopterin were tested for in vitro protective effect on chromosome aberrations in peripheral human lymphocytes using cytochalasin‐B blocked micronucleus (CBMN) assay. The new compound exerted a beneficial effect by decreasing DNA damage of human lymphocytes.