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Screening of Biological Activities of a Series of Chalcone Derivatives against Human Pathogenic Microorganisms
Author(s) -
Karaman İsa,
Gezegen Hayreddin,
Gürdere M. Burcu,
Dingil Alparslan,
Ceylan Mustafa
Publication year - 2010
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.200900027
Subject(s) - chalcone , chemistry , furfural , thiophene , antifungal , antimicrobial , minimum inhibitory concentration , organic chemistry , aqueous solution , antibacterial activity , condensation , elemental analysis , nuclear chemistry , combinatorial chemistry , bacteria , microbiology and biotechnology , genetics , biology , catalysis , thermodynamics , physics
In an effort to develop new antimicrobial agents, a series of chalcone derivatives, 3 – 60 , were prepared by Claisen – Schmidt condensation of appropriate acetophenones and 2‐furyl methyl ketones with appropriate aromatic aldehydes, furfural, and thiophene‐2‐carbaldehyde in an aqueous solution of NaOH and EtOH at room temperature. The synthesized compounds were characterized by means of their IR‐ and NMR‐spectral data, and elemental analysis. All compounds were tested for their antibacterial and antifungal activities by the disc diffusion method. For the most active compounds, also minimum inhibitory concentrations ( MIC s) were determined.