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Two New Sesquiterpene Derivatives from the Tunisian Endemic Ferula tunetana Pom .
Author(s) -
Jabrane Aymen,
Jannet Hichem Ben,
Mighri Zine,
Mirjolet JeanFrançois,
Duchamp Olivier,
HarzallahSkhiri Féthia,
LacailleDubois MarieAleth
Publication year - 2010
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.200900025
Subject(s) - sesquiterpene , stigmasterol , chemistry , coumarin , stereochemistry , terpene , cancer cell lines , cytotoxicity , two dimensional nuclear magnetic resonance spectroscopy , propiophenone , traditional medicine , organic chemistry , biochemistry , ketone , chromatography , cancer , in vitro , cancer cell , biology , medicine , genetics
A new sesquiterpene ester, tunetanin A ( 1 ), a new sesquiterpene coumarin, tunetacoumarin A ( 2 ), together with eight known compounds, i.e. , coladin ( 3 ), coladonin ( 4 ), isosmarcandin ( 5 ), 13‐hydroxyfeselol ( 6 ), umbelliprenin ( 7 ) propiophenone ( 8 ), β ‐sitosterol ( 9 ), and stigmasterol ( 10 ), were isolated from the roots of Ferula tunetana. Their structures were elucidated on the basis of extensive spectroscopic methods, including 1D‐ and 2D‐NMR experiments and MS analysis, as well as by comparison with published data. The cytotoxicity of compounds 1 – 7 towards two human colon cancer cell lines, HT‐29 and HCT 116, was evaluated. Compounds 3, 4 , and 6 showed weak cytotoxic activities.