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Adsorption of the Pt II Anticancer Drug Carboplatin by Mesoporous Silica
Author(s) -
Di Pasqua Anthony J.,
Wallner Silvia,
Kerwood Deborah J.,
Dabrowiak James C.
Publication year - 2009
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.200900021
Subject(s) - chemistry , carboplatin , mesoporous silica , drug , adsorption , mesoporous material , combinatorial chemistry , nuclear chemistry , pharmacology , biochemistry , organic chemistry , catalysis , chemotherapy , medicine , cisplatin
MCM‐41, a mesoporous silica nanomaterial with a high surface area for adsorption of small molecules, is a potential new type of delivery vehicle for therapeutic and diagnostic agents. In this report, we show that MCM‐41 adsorbs the front‐line anticancer drug carboplatin, [Pt(CBDCA‐ O , O′ )(NH 3 ) 2 ] (CBDCA=cyclobutane‐1,1‐dicarboxylate; 1 ), which is used to treat ovarian, lung, and other types of cancer. UV/Visible difference absorption spectroscopy shows that MCM‐41 adsorbs 1.8±0.2% of its own weight of carboplatin after a 24 h exposure to 26.9 m M drug in H 2 O. The pseudo ‐first‐order rate constant for adsorption of carboplatin by MCM‐41, measured using [ 1 H, 15 N] heteronuclear single quantum coherence (HSQC) NMR, and 15 N‐labeled carboplatin is k 1 =2.92±2.17×10 −6 s −1 at ca. 25°.