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A Novel Cytotoxic Cerium Complex: Aquatrichloridobis(1,10‐phenanthroline)cerium(III) (KP776). Synthesis, Characterization, Behavior in H 2 O, Binding towards Biomolecules, and Antiproliferative Activity
Author(s) -
Biba Florian,
Groessl Michael,
Egger Alexander,
Jakupec Michael A.,
Keppler Bernhard K.
Publication year - 2009
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.200900011
Subject(s) - chemistry , cerium , biomolecule , phenanthroline , capillary electrophoresis , lanthanide , in vitro , elemental analysis , nucleotide , stereochemistry , biochemistry , inorganic chemistry , chromatography , organic chemistry , gene , ion
The lanthanide complex aquatrichloridobis(1,10‐phenanthroline)cerium(III) [Ce(phen) 2 (H 2 O)Cl 3 ] (KP776) was fully characterized by elemental analysis, IR‐, and 1 H‐ and 13 C‐NMR spectroscopy, as well as TG/DTA measurements, and its behavior in H 2 O, important for the application as a chemotherapeutic, was studied. In addition, the binding of KP776 to nucleotides and single serum proteins was investigated by capillary electrophoresis, whereas binding to proteins in human plasma was observed by ICP‐MS. The compound shows promising anticancer properties in vitro : proliferation of human cancer cell lines is strongly inhibited with IC 50 values in the very low micromolar range.