Premium
Polycyclic Polyprenylated Acylphloroglucinols and Chromone O ‐Glucosides from Hypericum henryi subsp. uraloides
Author(s) -
Chen XuanQin,
Li Yan,
Cheng Xiao,
Wang Kou,
He Juan,
Pan ZhengHong,
Li MingMing,
Peng LiYan,
Xu Gang,
Zhao QinShi
Publication year - 2010
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.200900009
Subject(s) - chromone , chemistry , stereochemistry , epimer , two dimensional nuclear magnetic resonance spectroscopy , cytotoxic t cell , biochemistry , in vitro
Two new C(30) ‐epimeric polycyclic polyprenylated acylphloroglucinols (PPAPs), named uralodins B and C ( 1 and 2 , resp.), were isolated from the aerial parts of Hypericum henryi subsp. uraloides together with two new chromone glucosides, urachromones A and B ( 3 and 4 , resp.), as well as 16 known compounds. Their structures were established by extensive NMR techniques and MS analysis. The epimers 1 and 2 always behaved like a single compound when examined by TLC, and were separated by HPLC. Their configuration was distinguished by comparative analysis of the NMR data with known analogues together with the ROESY experiment. All the isolated PPAPs were evaluated for their cytotoxic activities against HepG2, SGC7901, HL‐60, and K562 cell lines. Compound 1 showed modest cytotoxic activities against SGC7901 and HL‐60 cell lines, and 2 showed modest cytotoxic activities against HepG2, SGC7901, HL‐60, and K562 cell lines.