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Novel Endothall‐Containing Platinum(IV) Complexes: Synthesis, Characterization, and Cytotoxic Activity
Author(s) -
Reithofer Michael R.,
Valiahdi Seied M.,
Galanski Mathea Sophia,
Jakupec Michael A.,
Arion Vladimir B.,
Keppler Bernhard K.
Publication year - 2008
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.200890197
Subject(s) - chemistry , hela , hydrobromide , cytotoxicity , hepatocellular carcinoma , bromide , stereochemistry , carcinoma , nuclear chemistry , cancer research , biochemistry , in vitro , organic chemistry , pathology , biology , medicine
Two platinum(IV) complexes ( OC ‐6‐33)‐dichlorido(ethane‐1,2‐diamine)dihydroxidoplatinum( IV ) and ( OC ‐6‐33)‐diammine(dichlorido)dihydroxidoplatinum( IV ) were carboxylated using demethylcantharidin as carboxylation agent. The complexes were characterized by elemental analysis, mass spectrometry, multinuclear ( 1 H, 13 C, 15 N, and 195 Pt) NMR spectroscopy, and, in case of ( OC ‐6‐33)‐diamminebis(3‐carboxy‐7 exo ‐oxabicyclo[2.2.1]heptane‐2‐carboxylato)dichloridoplatinum(IV) via X‐ray diffraction. Cytotoxicity of the complexes was studied in seven human cancer cell lines representing five tumor entities, i.e. , ovarian carcinoma (CH1, SK‐OV‐3), cervical carcinoma (HeLa), colon carcinoma (SW480, HCT‐116), osteosarcoma (U‐2 OS), and hepatocellular carcinoma (Hep G2) by means of the MTT (=3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyl‐2 H ‐tetrazolium hydrobromide) assay.
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