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The Hydration of Chloroacetonitriles Catalyzed by Mono‐ and Dinuclear Ru II ‐ and Os II ‐Arene Complexes
Author(s) -
Ashraf Shaheen M.,
Kandioller Wolfgang,
MendozaFerri MariaGrazia,
Nazarov Alexey A.,
Hartinger Christian G.,
Keppler Bernhard K.
Publication year - 2008
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.200890188
Subject(s) - chemistry , selectivity , yield (engineering) , catalysis , ligand (biochemistry) , hydrolysis , substrate (aquarium) , transition metal , medicinal chemistry , stereochemistry , combinatorial chemistry , organic chemistry , receptor , biochemistry , materials science , oceanography , metallurgy , geology
The hydration of nitriles to the corresponding amides is an important reaction for both laboratory and industry purposes. The classical synthesis method requires harsh conditions, gives low yields, and is nonselective due to further hydrolysis of the amides into carboxylic acids. To obtain good yields and high selectivity, transition metal complexes have been utilized as catalysts for this transformation. Herein, a series of Ru II ‐ and Os II ‐arene complexes – based on pyranone, thiopyranone, and pyridinone ligands – were assayed on the hydration of chloroacetonitriles. The influence of the substitution pattern of the ligand, and of the nuclearity and of the type of substrate on the yield, the selectivity, and the turnover numbers are discussed.