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DNA Binding, Photocleavage, and Topoisomerase Inhibition of Functionalized Ruthenium(II)‐Polypyridine Complexes
Author(s) -
Gao Feng,
Chao Hui,
Ji LiangNian
Publication year - 2008
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.200890181
Subject(s) - ruthenium , chemistry , dna , topoisomerase , combinatorial chemistry , selectivity , stereochemistry , ligand (biochemistry) , binding site , mechanism (biology) , biochemistry , catalysis , receptor , philosophy , epistemology
The interaction of ruthenium(II)‐polypyridyl complexes with DNA has attracted considerable interests during the past two decades. This paper presents some recent progresses in our laboratory on the interaction of Ru II ‐polypyridyl complexes with DNA. The first part describes the effect of modulating the intercalative ligand on the DNA‐binding behaviors of the complexes, such as DNA‐binding affinity, DNA‐binding enantioselectivity, DNA molecular ‘light switch’ effect, and DNA sequence selectivity. The second part focuses on the DNA photocleavage by the complexes and its mechanism. In the final part, we discuss the topoisomerase inhibition and its mechanism, as well as the antitumor activity of the Ru II ‐polypyridyl complexes.