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Pentacyclic Triterpenoids from the Aerial Parts of Lantana camara and Their Nematicidal Activity
Author(s) -
Begum Sabira,
Zehra Syeda Qamar,
Siddiqui Bina Shaheen,
Fayyaz Shahina,
Ramzan Musarrat
Publication year - 2008
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.200890173
Subject(s) - lantana camara , triterpenoid , chemistry , triterpene , oleanolic acid , lantana , terpene , botany , stereochemistry , traditional medicine , biology , medicine , alternative medicine , pathology
Two new olean‐12‐ene triterpenoids, camarolic acid ( 1 ) and lantrigloylic acid ( 2 ), have been isolated from the aerial parts of Lantana camara , along with ten known triterpenes, namely, camaric acid, lantanolic acid, lantanilic acid, pomolic acid, camarinic acid, lantoic acid, camarin, lantacin, camarinin, and ursolic acid. The new compounds have been characterized as 3,25‐epoxy‐3 α ‐hydroxy‐22 β ‐{[( S )‐3‐hydroxy‐2‐methylidenebutanoyl]oxy}olean ‐ 12‐en‐28‐oic acid ( 1 ) and 3,25‐epoxy‐3 α ‐hydroxy‐22 β ‐[(3‐methylbut‐2‐enoyl)oxy]olea ‐ 9(11),12‐dien‐28‐oic acid ( 2 ) through spectroscopic studies and a chemical transformation. Seven of the constituents, namely pomolic acid, lantanolic acid, lantoic acid, camarin, lantacin, camarinin, and ursolic acid, were tested for nematicidal activity against root‐knot nematode Meloidogyne incognita. Pomolic acid, lantanolic acid, and lantoic acid showed 100% mortality at 1 mg/ml concentration after 24 h, while camarin, lantacin, camarinin, and ursolic acid exhibited 100% mortality at this concentration after 48 h. These results are comparable to those obtained with the conventional nematicide furadan (100% mortality at 1 mg/ml concentration after 24 h).