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Synthesis and Biological Evaluation of 4 β ‐[(4‐Substituted)‐1,2,3‐triazol‐1‐yl]podophyllotoxins as Potential Anticancer Agents
Author(s) -
Reddy Pitta Bhaskar,
Agrawal Satyam Kumar,
Singh Swaran,
Bhat Bilal A.,
Saxena Ajit K.,
Kumar Halmuthur M. Sampath,
Qazi Gulam N.
Publication year - 2008
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.200890168
Subject(s) - podophyllotoxin , chemistry , click chemistry , cytotoxic t cell , combinatorial chemistry , cancer cell lines , cell culture , stereochemistry , cancer , biochemistry , cancer cell , in vitro , biology , genetics , medicine
A series of novel 4 β ‐[(4‐substituted)‐1,2,3‐triazol‐1‐yl]podophyllotoxin derivatives were synthesized by employing Cu I ‐catalyzed click chemistry and evaluated for their anticancer activity against a panel of seven human cancer cell lines (HT‐29, HCT‐15, 502713, HOP‐62, A‐549, MCF‐7, and SF‐295). The compounds 9b, 9c, 9e, 9f , and 9h showed significant cytotoxic activities especially against HT‐29, HCT‐15, 502713 cell lines.