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Alkaloids from the Roots of Zanthoxylum nitidum and Their Antiviral and Antifungal Effects
Author(s) -
Yang Guohong,
Chen Daofeng
Publication year - 2008
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.200890160
Subject(s) - antifungal , chemistry , zanthoxylum , traditional medicine , stereochemistry , in vitro , biochemistry , biology , microbiology and biotechnology , medicine
Five alkaloids, 5,6‐dihydro‐6‐methoxynitidine ( 1 ), dictamnine ( 2 ), γ ‐fagarine ( 3 ), skimmianine ( 4 ), and 5‐methoxydictamnine ( 5 ), were isolated from the roots of Zanthoxylum nitidum. Their structures and configurations were elucidated by spectroscopic methods and X‐ray analysis. Compounds 1, 4 , and 5 showed in vitro antiviral effect against hepatitis B virus, and compounds 2, 3 , and 5 demonstrated marked antimitotic and antifungal activity.