Alkaloids from the Roots of  Zanthoxylum nitidum  and Their Antiviral and Antifungal Effects | Zendy

Yang Guohong | Zendy; Chen Daofeng | Zendy

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Alkaloids from the Roots of Zanthoxylum nitidum and Their Antiviral and Antifungal Effects

Author(s) -

Yang Guohong,

Chen Daofeng

Publication year - 2008

Publication title -

chemistry and biodiversity

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.427

H-Index - 70

eISSN - 1612-1880

pISSN - 1612-1872

DOI - 10.1002/cbdv.200890160

Subject(s) - antifungal , chemistry , zanthoxylum , traditional medicine , stereochemistry , in vitro , biochemistry , biology , microbiology and biotechnology , medicine

Five alkaloids, 5,6‐dihydro‐6‐methoxynitidine ( 1 ), dictamnine ( 2 ), γ ‐fagarine ( 3 ), skimmianine ( 4 ), and 5‐methoxydictamnine ( 5 ), were isolated from the roots of Zanthoxylum nitidum. Their structures and configurations were elucidated by spectroscopic methods and X‐ray analysis. Compounds 1, 4 , and 5 showed in vitro antiviral effect against hepatitis B virus, and compounds 2, 3 , and 5 demonstrated marked antimitotic and antifungal activity.

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