Premium
Capnellenes from the Soft Coral Dendronephthya rubeola
Author(s) -
Grote Daniela,
Hänel Frank,
Dahse HansMartin,
Seifert Karlheinz
Publication year - 2008
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.200890157
Subject(s) - hela , chemistry , coral , cell culture , cytotoxic t cell , nuclear magnetic resonance spectroscopy , cancer research , stereochemistry , microbiology and biotechnology , biochemistry , cell , genetics , biology , ecology , in vitro
Four new acetoxycapnellenes 1 – 4 , the first epoxyprecapnellene 5 , along with the known dihydroxycapnellene 6 and monoacetoxycapnellene 7 , have been isolated from the soft coral Dendronephthya rubeola. The structures were determined primarily by NMR spectroscopy. The compounds 6 and 7 showed a good antiproliferative activity against the cell line L‐929 (murine fibroblasts) and a good cytotoxic activity against the HeLa (human cervix carcinoma) cell line. Compound 6 strongly inhibits the interaction of the oncogenic transcription factor Myc with its partner protein Max. Myc/Max‐Interaction inhibitors are therapeutically interesting compounds in oncology.