Capnellenes from the Soft Coral  Dendronephthya rubeola | Zendy

Grote Daniela | Zendy; Hänel Frank | Zendy; Dahse HansMartin | Zendy; Seifert Karlheinz | Zendy

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Capnellenes from the Soft Coral Dendronephthya rubeola

Author(s) -

Grote Daniela,

Hänel Frank,

Dahse HansMartin,

Seifert Karlheinz

Publication year - 2008

Publication title -

chemistry and biodiversity

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.427

H-Index - 70

eISSN - 1612-1880

pISSN - 1612-1872

DOI - 10.1002/cbdv.200890157

Subject(s) - hela , chemistry , coral , cell culture , cytotoxic t cell , nuclear magnetic resonance spectroscopy , cancer research , stereochemistry , microbiology and biotechnology , biochemistry , cell , genetics , biology , ecology , in vitro

Four new acetoxycapnellenes 1 – 4 , the first epoxyprecapnellene 5 , along with the known dihydroxycapnellene 6 and monoacetoxycapnellene 7 , have been isolated from the soft coral Dendronephthya rubeola. The structures were determined primarily by NMR spectroscopy. The compounds 6 and 7 showed a good antiproliferative activity against the cell line L‐929 (murine fibroblasts) and a good cytotoxic activity against the HeLa (human cervix carcinoma) cell line. Compound 6 strongly inhibits the interaction of the oncogenic transcription factor Myc with its partner protein Max. Myc/Max‐Interaction inhibitors are therapeutically interesting compounds in oncology.

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