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Dendritic Nucleotides: Interaction with an Aliphatic Acid Monolayer
Author(s) -
Wang Guojie,
Abramov Mikhail,
Van Aerschot Arthur,
Rozenski Jef,
Lei Shengbin,
Klymchenko Andrei,
Van der Auweraer Mark,
De Feyter Steven,
Herdewijn Piet
Publication year - 2008
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.200890156
Subject(s) - dendrimer , chemistry , nucleotide , monolayer , reagent , branching (polymer chemistry) , phosphoramidite , stereochemistry , biophysics , biochemistry , organic chemistry , dna , oligonucleotide , biology , gene
Dendrimeric‐T and dendrimeric‐A with 36 nucleotides were synthesized using phosphoramidite reagents. These dendrimers contain the nucleosides dA and dT, which are the components of the dA‐dT base pair. Branching was obtained using a bifurcated and trifurcated reagent. The dendrimers were purified by ion‐exchange chromatography. No specific interactions between these dendrimers were observed using atomic force microscopy. However, the dendrimeric‐T is able to disrupt monolayers of fatty acids, resulting in a reorientation of the lipids (from head‐to‐tail to head‐to‐head) as demonstrated by scanning tunneling microscopy (STM).