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Action Mechanism of Insulin‐Mimetic Vanadyl–Allixin Complex
Author(s) -
Hiromura Makoto,
Sakurai Hiromu
Publication year - 2008
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.200890149
Subject(s) - insulin , mechanism of action , chemistry , type 2 diabetes mellitus , hypoglycemia , mechanism (biology) , type 2 diabetes , diabetes mellitus , medicine , endocrinology , pharmacology , biochemistry , in vitro , epistemology , philosophy
Abstract In the 21st century, there has been a dramatic worldwide increase in the prevalence of metabolic syndromes, including diabetes mellitus (DM). Several synthetic pharmaceutical agents have been developed and used for the treatment of type‐2 DM; however, these compounds have several problems such as side effects, hypoglycemia, and weight gain. Therefore, new drugs are required for DM therapy. We have proposed that some vanadyl complexes function as potent insulin‐mimetic and antidiabetic agents in type‐1 and type‐2 DM animal models. In this article, we review the possible action mechanism of insulin‐mimetic and antidiabetic vanadyl complexes, focusing on a recently proposed complex, bis(allixinato)oxovanadium(IV), with respect to the insulin‐signaling pathway in cultured adipocytes.