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Argusides D and E, Two New Cytotoxic Triterpene Glycosides from the Sea Cucumber Bohadschia argus Jaeger
Author(s) -
Liu BaoShu,
Yi YangHua,
Li Ling,
Sun Peng,
Han Hua,
Sun GuoQuan,
Wang XiaoHua,
Wang ZengLei
Publication year - 2008
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.200890131
Subject(s) - triterpene , aglycone , chemistry , glycoside , sea cucumber , stereochemistry , tetrasaccharide , two dimensional nuclear magnetic resonance spectroscopy , biochemistry , biology , polysaccharide , medicine , ecology , alternative medicine , pathology
Two new triterpene glycosides, argusides D and E ( 1 and 2 , resp.), have been isolated from the sea cucumber Bohadschia argus Jaeger collected in the South China Sea. Their structures have been established by spectral analysis (ESI‐MS, and 1D‐ and 2D‐NMR) and chemical evidence. Compounds 1 and 2 both possess an holostane‐type triterpene aglycone with a C(9)C(11) bond, an OH group at C(12), and tetrasaccharide moieties, but differ in the side chains. The two glycosides exhibited significant cytotoxicities against four human tumor cell lines, A549, HCT‐116, HepG2, and MCF‐7.