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A New Dihydroagarofuranoid Sesquiterpene and Antituberculosis Constituents from the Root of Microtropis japonica
Author(s) -
Chou TsungHsien,
Chen IhSheng,
Peng ChienFang,
Sung PingJyun,
Chen JihJung
Publication year - 2008
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.200890129
Subject(s) - sesquiterpene , chemistry , stereochemistry , mycobacterium tuberculosis , japonica , in vitro , traditional medicine , botany , biochemistry , tuberculosis , biology , medicine , pathology
A new dihydroagarofuran‐based sesquiterpene, 15‐acetoxyorbiculin A ( 1 ), was isolated from the root of Microtropis japonica , together with 13 known compounds. Their structures were determined through in‐depth spectroscopic and mass‐spectrometric analyses. Among the isolated compounds, celahin C ( 6 ) and salasol A ( 7 ) exhibited potent in vitro antituberculosis activity, both with an MIC value of 15.0 μg/ml against Mycobacterium tuberculosis H 37 Rv.