A New Dihydroagarofuranoid Sesquiterpene and Antituberculosis Constituents from the Root of  Microtropis japonica | Zendy

Chou TsungHsien | Zendy; Chen IhSheng | Zendy; Peng ChienFang | Zendy; Sung PingJyun | Zendy; Chen JihJung | Zendy

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A New Dihydroagarofuranoid Sesquiterpene and Antituberculosis Constituents from the Root of Microtropis japonica

Author(s) -

Chou TsungHsien,

Chen IhSheng,

Peng ChienFang,

Sung PingJyun,

Chen JihJung

Publication year - 2008

Publication title -

chemistry and biodiversity

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.427

H-Index - 70

eISSN - 1612-1880

pISSN - 1612-1872

DOI - 10.1002/cbdv.200890129

Subject(s) - sesquiterpene , chemistry , stereochemistry , mycobacterium tuberculosis , japonica , in vitro , traditional medicine , botany , biochemistry , tuberculosis , biology , medicine , pathology

A new dihydroagarofuran‐based sesquiterpene, 15‐acetoxyorbiculin A ( 1 ), was isolated from the root of Microtropis japonica , together with 13 known compounds. Their structures were determined through in‐depth spectroscopic and mass‐spectrometric analyses. Among the isolated compounds, celahin C ( 6 ) and salasol A ( 7 ) exhibited potent in vitro antituberculosis activity, both with an MIC value of 15.0 μg/ml against Mycobacterium tuberculosis H 37 Rv.

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