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Two New Triterpene Saponins from the Anti‐Inflammatory Saponin Fraction of Ilex pubescens Root
Author(s) -
Wang JingRong,
Zhou Hua,
Jiang ZhiHong,
Liu Liang
Publication year - 2008
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.200890125
Subject(s) - saponin , triterpene , chemistry , fraction (chemistry) , stereochemistry , carrageenan , glycoside , anti inflammatory , traditional medicine , biochemistry , chromatography , pharmacology , biology , medicine , alternative medicine , pathology
The saponin fraction from the ethanolic extracts of the root of Ilex pubescens Hook . et Arn . (Ilexaceae) was found to exhibit potent anti‐inflammatory effects on carrageenan‐induced paw edema in rats. Two novel triterpene saponins, pubescenosides C and D ( 1 and 2 , resp.), together with five known saponins were isolated from this saponin fraction. The structures of 1 and 2 were elucidated as (20 β )‐3‐ O ‐[ β ‐ D ‐glucopyranosyl‐(1→2)‐ β ‐ D ‐xylopyranosyl]ursa‐12,18‐dien‐28‐oic acid 28‐ O ‐ β ‐ D ‐glucopyranosyl ester, and (20 β )‐3‐ O ‐[ α ‐ L ‐rhamnopyranosyl‐(1→2)‐ β ‐ D ‐glucopyranosyl‐(1→2)‐ β ‐ D ‐xylopyranosyl]ursa‐ 12,18‐dien‐28‐oic acid 28‐ O ‐ β ‐ D ‐glucopyranosyl ester, respectively, on the basis of chemical and spectroscopic data. Five known saponins isolated from the saponin fraction were identified as ilexsaponin B 1 , B 2 , B 3 , A 1 , and chikusetsusaponin IV a ( 3 – 7 , resp.).