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Natural Inhibitors of DNA Topoisomerase I with Cytotoxicities
Author(s) -
Han HongJin,
Tan NingHua,
Zeng GuangZhi,
Fan JunTing,
Huang HuoQiang,
Ji ChangJiu,
Jia RuiRui,
Zhao QinShi,
Zhang YingJun,
Hao XiaoJiang,
Wang LiQin
Publication year - 2008
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.200890124
Subject(s) - topoisomerase , chemistry , topoisomerase inhibitor , dna , cancer cell lines , cell culture , cytotoxicity , biochemistry , cancer cell , cancer , biology , genetics , in vitro
DNA Topoisomerase I can cause DNA breaks and play a key role during cell proliferation and differentiation. It is an important target for anticancer agents. While screening for anticancer compounds, seven natural compounds, 1 – 7 , showed potent cytotoxicities against a panel of ten cancer cell lines. Moreover, an inhibition assay demonstrated that they are also DNA topoisomerase I inhibitors, in which inhibitors 1 – 5 are new ones.
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