Premium
A New Indole Alkaloid and Anti‐Inflammatory Constituents from Strychnos cathayensis
Author(s) -
Chen JihJung,
Luo YuTing,
Hwang TsongLong,
Sung PingJyun,
Wang TaiChi,
Chen IhSheng
Publication year - 2008
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.200890122
Subject(s) - chemistry , strychnos , indole test , alkaloid , indole alkaloid , stereochemistry , superoxide , elastase , ether , anti inflammatory , biochemistry , organic chemistry , pharmacology , enzyme , medicine
Abstract A new indole alkaloid, 11,12‐dimethoxyhenningsamine ( 1 ), was isolated from the roots of Strychnos cathayensis , together with 19 known compounds. The structure of this new compound was determined through spectroscopic and mass‐spectrometric analyses. Among the isolated compounds, 11‐methoxyhenningsamine ( 3 ) and aesculetin dimethyl ether ( 4 ) exhibited potent inhibition ( IC 50 <5.5 μg/ml) on superoxide‐anion generation and elastase release by human neutrophils in response to fMet‐Leu‐Phe/cytochalasin B.