A New Indole Alkaloid and Anti‐Inflammatory Constituents from  Strychnos cathayensis | Zendy

Chen JihJung | Zendy; Luo YuTing | Zendy; Hwang TsongLong | Zendy; Sung PingJyun | Zendy; Wang TaiChi | Zendy; Chen IhSheng | Zendy

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A New Indole Alkaloid and Anti‐Inflammatory Constituents from Strychnos cathayensis

Author(s) -

Chen JihJung,

Luo YuTing,

Hwang TsongLong,

Sung PingJyun,

Wang TaiChi,

Chen IhSheng

Publication year - 2008

Publication title -

chemistry and biodiversity

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.427

H-Index - 70

eISSN - 1612-1880

pISSN - 1612-1872

DOI - 10.1002/cbdv.200890122

Subject(s) - chemistry , strychnos , indole test , alkaloid , indole alkaloid , stereochemistry , superoxide , elastase , ether , anti inflammatory , biochemistry , organic chemistry , pharmacology , enzyme , medicine

A new indole alkaloid, 11,12‐dimethoxyhenningsamine ( 1 ), was isolated from the roots of Strychnos cathayensis , together with 19 known compounds. The structure of this new compound was determined through spectroscopic and mass‐spectrometric analyses. Among the isolated compounds, 11‐methoxyhenningsamine ( 3 ) and aesculetin dimethyl ether ( 4 ) exhibited potent inhibition ( IC 50 <5.5 μg/ml) on superoxide‐anion generation and elastase release by human neutrophils in response to fMet‐Leu‐Phe/cytochalasin B.

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