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Argusides B and C, Two New Cytotoxic Triterpene Glycosides from the Sea Cucumber Bohadschia argus Jaeger
Author(s) -
Liu BaoShu,
Yi YangHua,
Li Ling,
Sun Peng,
Yuan WeiHua,
Sun GuoQuan,
Han Hua,
Xue Mei
Publication year - 2008
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.200890115
Subject(s) - triterpene , aglycone , chemistry , glycoside , stereochemistry , etoposide , moiety , sea cucumber , cytotoxic t cell , biochemistry , biology , in vitro , medicine , ecology , alternative medicine , pathology , chemotherapy , genetics
Two new triterpene glycosides, argusides B and C ( 1 and 2 , resp.), have been isolated from the sea cucumber Bohadschia argus Jaeger collected in the South China Sea. Their structures have been established by spectral analysis (2D‐NMR and ESI‐MS) and chemical evidence. Compounds 1 and 2 both possess a holostane‐type triterpene aglycone with a C(9)C(11) bond and a OH group at C(12), but differ in their substituents at C(17) and the hexasaccharide moiety. The two glycosides exhibited significant cytotoxicities against four human tumor cell lines (A549, HCT‐116, HepG2, and MCF‐7). In comparison with the positive control V‐16 (etoposide), 1 and 2 showed higher cytotoxicities to A549 and HCT‐116 cell lines.